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“It just now, for lack of a better phrase, has legs. “I enjoy it because it’s just so dumb and it means nothing,” continued Rudd.

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The actor added that he has since worked with Apatow, who has become more accepting of the Mac and Me joke. Nate Wright has the tendency to pull off the most, biggest. Principal Nichols always tries to stop the pranks but Nate Wright who is the 'Prank Master', always pulls a few off. The teachers, of course, very much disapprove. On Prank Day, students play pranks on other students and the teachers of P.S. “I just feel so gross telling anybody to see this,” Rudd said of promoting his films. It always takes place on the last day of school.

“It was the one time I think I actually showed a real clip on your show.” “There was also another time where he came and stopped it,” said Rudd of Apatow. While the director asked Rudd to not show the Mac and Me clip, he still went ahead and kept the tradition alive. The host then reminisced about a time Rudd appeared on the show to promote Judd Apatow’s This Is 40. “This is the first time that we even addressed it,” the actor added.

One fan even made a mashup of the clips from the many times Rudd has pulled the gag, which O’Brien noted “means nothing” and that there’s not point behind it. O’Brien said that fans have come to expect Rudd’s Mac and Me bit every time he appears on Conan. “I assume the budget was so low that there was this one maniacal laugh that the kid makes and every time in the movie, they just use the same laugh. This team of thugs are trying to track him down, trying to get this baby, and then they cut to the baby fighting a group of men and it’s clearly a stunt little person just beating up these guys,” he explained. “There’s a scene where a baby - I want to say they have this super baby in a lab, I don’t know - and he escapes.